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Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery

TitleDirecting Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery
Publication TypeJournal Article
Year of Publication2017
AuthorsLi, Bang Lin, Setyawati Magdiel I., Chen Linye, Xie Jianping, Ariga Katsuhiko, Lim Chwee-Teck, Garaj Slaven, and Leong David Tai
JournalACS Appl. Mater. Interfaces
Date Published05/2017
Keywords2-dimensional mos2, 3D cell culture, cancer, DNA functionalization, functionalization, graphene sheets, layer mos2, layer-by-layer assembly, molybdenum disulfide, molybdenum-disulfide, nanoparticles, nanostructures, systems, targeted chemotherapy, therapy

Layer-by-layer (LbL) self-assembled stacked Testudo-like MoS2 superstructures carrying cancer drugs are formed from nanosheets controllably assembled with sequence-based DNA oligonucleotides. These superstructures can disassemble autonomously in response to cancer cells' heightened ATP metabolism. First, we functionalize MoS2 nanosheets (MoS2-NS) nanostructures with DNA oligonucleotides having thiol-terminated groups (DNA/MoS2-NS) via strong binding to sulfur atom defect vacancies on MoS2 surfaces. The driving force to assemble into a higher-order DNA/MoS2-NS superstructure is guided by a linker aptamer that induced interlayer assembly. In the presence of target ATP molecules, these multilayer superstructures disassembled as a consequence of stronger binding of ATP molecules with the linking aptamers. This design plays a dual role of protection and delivery by LbL stacked MoS2-NS similar in concept to a Greek Testudo. These superstructures present a protective armor-like shell of MoS2-NS, which still remains responsive to small and infiltrating ATP molecules diffusing through the protective MoS2NS, contributing to an enhanced stimuli-responsive drug release system for targeted chemotherapy.


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