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Highly Sensitive and Selective Aptamer-Based Fluorescence Detection of a Malarial Biomarker Using Single-Layer MoS2 Nanosheets

TitleHighly Sensitive and Selective Aptamer-Based Fluorescence Detection of a Malarial Biomarker Using Single-Layer MoS2 Nanosheets
Publication TypeJournal Article
Year of Publication2016
Authors, Geldert Alisha, Zhang Xiao, Zhang Hua, and Lim Chwee Teck
JournalACS Sens.
Volume1
Pagination1315–1321
Date Published11/2016
ISSN2379-3694
Keywords2D nanomaterials, aptamers, aptasensors, dna, Graphene oxide, malarial biomarker, microscopy, MoS2, Nanomaterials, Plasmodium lactate dehydrogenase (pLDH), plasmodium lactate-dehydrogenase, pldh, rapid diagnostic-test, sensors, tests, Transition metal dichalcogenides
Abstract

We demonstrate a highly selective and sensitive aptamer-based "capture-release" fluorescence detection of a malarial biomarker, i.e., Plasmodium lactose dehydrogenase (pLDH) protein, using single-layer two-dimensional MoS2 nanosheets. The detection of the target pLDH protein utilizing the aptamer-nanosheet sensing platform is rapid and can be easily completed within 10 min. In addition, the developed biomolecular sensor is capable of detecting the target malarial biomarker in homogeneous protein solutions as well as in heterogeneous mixtures of proteins. We anticipate that the ultrathin MoS2 nanosheet-based biosensor will facilitate the further development of biomolecular nanosensors for the detection of a wide range of biomarkers for malaria and other diseases.

DOI10.1021/acssensors.6b00449

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